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Responsible and judicious anabolic steroid use among healthy adult males is a significantly different situation in comparison to anabolic steroid use among children, teenagers, and females, which may have serious implications for the health risk of these age groups. The aim of this preliminary study was to study the effects of the consumption of the anabolic steroid Anavar (AvaPro) in healthy male subjects, particularly the effects of Anavar on semen quality. In a previous study, we showed that the consumption of the anabolic steroid Anavar by healthy subjects may adversely affect semen quality (Kerstetter et al, 2009). We aimed to study the effects of this steroid on seminal parameters in healthy male subjects to obtain a better insight into this phenomenon and explore whether these effects were related to its effects on testosterone and its binding to the target organs [testosterone transporter (TAT) and testosterone receptor (TR)] (Hochberg et al, 2009). In this preliminary study, we focused on the effects of Anavar ingestion in young healthy male subjects (18–23 years of age) to ascertain whether this steroid affects the sexual organs [cervix (VC) and seminal vesicles (VP)] and how it affects sperm production and motility, respectively. Materials and methods Subjects and procedure The study was conducted in two steps. In the first step of the study, 16 healthy males were recruited through the university community, and they were screened and assigned without any pre-specified criteria to the study. All participants had normal body weight (BMI = 22.8–24.8 kg/m2) at the beginning of the study [according to self-report]. They were also required to have a normal sperm production index (SPM) index. During study design, we used the following criteria for participants: no more than one past-month period of steroid use, normal sperm count [normal sperm count (NMCS/NCDS) ≥ 20 × 106/ml and total sperm count (TC/TCS) ≥ 20 × 104/ml] and a normal TAT index (TC/TCS ≥ 4 × 106/ml). Exclusion criteria were pregnancy-related conditions, any other condition that might interfere with the study or which was suspected of interfering with a good outcome of the study in any way, and any other drug or substance that might have influenced our outcome measures as the primary outcome measure. For this study, participants received a drug package from the study researcher (DMS; Uppsala University, Uppsala, SWED). This drug package consisted of 5 days of An Related Article: